Papulo-Necrotic Tuberculide

Papulonecrotic Tuberculide in a Three-year-old Child

History A three-year-old girl presented with a two-year history of recurrent , bi lateral ly distributed, asymptomatic papules mainly affecting the extensor surfaces of the upper and lower limbs. The lesions progressed to form pustules, crusts and were increasing in number. Some of these lesions healed with scarring and pigmentation. The girl was otherwise healthy with no systemic complaint or ...

Acute Necrotic Parotitis

Procoagulant platelets: are they necrotic?

Apoptosis and necrosis represent distinct cell death processes that regulate mammalian development, physiology and disease. Apoptosis characteristically leads to the silent destruction and removal of cells in the absence of an inflammatory response. In contrast, necrotic cell death can induce physiologic inflammatory responses linked to tissue defense and repair. Although anucleate, platelets u...

Necrotic Inflammatory Reaction to Muramyl

N-Acetylmuramyi-L-alanyl-D-isoglutamine (muramyl dipeptide, MDP) 1 was shown (1) to be the minimal and essential s t ructure requi red for adjuvant activity o f bacterial cell wall peptidoglycans. Fur ther , MDP has been found to possess various biological activities, o ther than adjuvant activity, that are exer ted by bacterial cell wall peptidoglycans. Since MDP is such a potent immunomodula ...

Necrotic cell death and neurodegeneration

Necrosis, one of the two main types of cell death, contributes critically in many devastating pathological conditions in human, including stroke, ischemia, trauma and neurodegenerative diseases. However, unlike apoptosis, the molecular mechanisms underlying necrotic cell death and neurodegeneration are poorly understood. Caenorhabditis elegans offers a powerful platform for a thorough and syste...